Preparing for the future with nanoparticles
Known substances that are milled into nanoparticles take on new properties. Active ingredi
Nanotechnology refers to the production, analysis, and application of structures that are at least one dimension smaller than 100 nanometers. The particles are 1,000 times thinner than the diameter of a human hair.
Think big, go small
The use of nanotechnology is not only increasing for surface treatments but is also delivering impressive results in the medical industry. Recent headlines have included: Drug-carrier nanoparticles very effective at killing liver cancer cells”, “Breakthrough in cancer research”, and “Nano vaccine in the battle against tumors”.
Frewitt, known for its innovations in the area of fine milling, has tackled the nano challenge with the development of a ground-breaking bead mill. This technical breakthrough is known as the NanoWitt. The device, developed for drug development & formulation, is further detailed hereafter.
Efficient down to the smallest detail
With the NanoWitt-Lab, materials can be wet milled down to a particle size of 50 nanometers (nm). The milling chamber’s modular construction is designed for milling quantities ranging from milligrams up to 1.5 kg. The specified range depends on the solids content.
The extremely compact lab device is easy to integrate and thanks to its intuitive control system, it can be set up and ready to work in a very short time. The innovative patented NanoWitt construction allows short milling time at low specific energy, this resulting in gentle product processing, no hot spot generation, lowest product contamination and tight particle size distribution. Its unique dynamic separator (DS) with no filter prevents clogging and hectic operation, which are steady problems with other technologies. In addition to providing stable processing conditions, the DS allows direct in-line sampling and integration of an in-line particle size measurement.
The NanoWitt cGMP design provides furthermore user-friendly operation and easy bead handling, this combined with high product recovery.
Modifications with a flick of the wrist
Frewitt has kept its proven modular system for changing the milling head on the FreDrive-Lab platform. With just a single tri-clamp, the particularly lightweight nano milling head is readily interchangeable on the platform and easy to integrate into a rigid or flexible isolator.
After removal, the milling head can be cleaned quickly and easily.
Wide scope of application
The NanoWitt-Lab is designed to mill all types of powders, delivering a homogeneous product whose particle size can be measured with a real-time PAT solution if desired. Batch or semi-batch processing along with simplified filling/emptying round off the technical features of the new bead mill for producing nanoparticles. The NanoWitt has blazed a trail into a new future, and now all we have to do is follow it together.